T. Conrad Gilliam

Research Summary
Marjorie I. and Bernard A. Mitchell Distinguished Service Professor of Human Genetics Dean for Basic Science, Biological Sciences Division My research focuses on the identification and characterization of heritable mutations that affect the nervous system. Research projects vary from genetic mapping of rare (Mendelian) disease mutations and characterization of their downstream consequences to the study of common heritable disorders using mouse models as well as genomic and bioinformatic approaches. I am collaborating with experts in data-mining and network topology, systems biology, large-scale computing, and statistical genetics to develop new approaches to map the multi-gene determinants of common neuropsychiatric disorders. By reducing possible gene-gene combinations to those documented in the literature or whole genome databases, we avoid the penalties of multiple-testing. We are also collaborating to build software solutions for large-scale data mining and data integration.
  • University of Missouri, Columbia, MO, PhD Biochemistry 1981
  • University of London, Paddington, London, Post-doc Fellow Molecular Genetics 1983
  • Harvard Medical School, Boston, Post-doc Fellow Molecular Genetics 1985
Biosciences Graduate Program Association
  1. Zhou X, Kurywchak P, Wolf-Dennen K, Che SPY, Sulakhe D, D'Souza M, Xie B, Maltsev N, Gilliam TC, Wu CC, McAndrews KM, LeBleu VS, McConkey DJ, Volpert OV, Pretzsch SM, Czerniak BA, Dinney CP, Kalluri R. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Mol Ther Methods Clin Dev. 2021 Sep 10; 22:360-376. View in: PubMed

  2. Kara S, Hanna A, Pirela-Morillo GA, Gilliam CT, Wilson GD. Molecular Interaction Network Approach (MINA) identifies association of novel candidate disease genes. MethodsX. 2019; 6:1286-1291. View in: PubMed

  3. Sulakhe D, D'Souza M, Wang S, Balasubramanian S, Athri P, Xie B, Canzar S, Agam G, Gilliam TC, Maltsev N. Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. Brief Bioinform. 2019 09 27; 20(5):1754-1768. View in: PubMed

  4. Xie B, Laxman B, Hashemifar S, Stern R, Gilliam TC, Maltsev N, White SR. Chemokine expression in the early response to injury in human airway epithelial cells. PLoS One. 2018; 13(3):e0193334. View in: PubMed

  5. Bainer RO, Trendowski MR, Cheng C, Pei D, Yang W, Paugh SW, Goss KH, Skol AD, Pavlidis P, Pui CH, Gilliam TC, Evans WE, Onel K. A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia. Cancer Manag Res. 2017; 9:397-410. View in: PubMed

  6. Sulakhe D, Xie B, Taylor A, D'Souza M, Balasubramanian S, Hashemifar S, White S, Dave UJ, Agam G, Xu J, Wang S, Gilliam TC, Maltsev N. Lynx: a knowledge base and an analytical workbench for integrative medicine. Nucleic Acids Res. 2016 Jan 04; 44(D1):D882-7. View in: PubMed

  7. Xie B, Agam G, Balasubramanian S, Xu J, Gilliam TC, Maltsev N, Börnigen D. Disease gene prioritization using network and feature. J Comput Biol. 2015 Apr; 22(4):313-23. View in: PubMed

  8. Dubchak I, Balasubramanian S, Wang S, Cem M, Meyden C, Sulakhe D, Poliakov A, Börnigen D, Xie B, Taylor A, Ma J, Paciorkowski AR, Mirzaa GM, Dave P, Agam G, Xu J, Al-Gazali L, Mason CE, Ross ME, Maltsev N, Gilliam TC. An integrative computational approach for prioritization of genomic variants. PLoS One. 2014; 9(12):e114903. View in: PubMed

  9. Sulakhe D, Taylor A, Balasubramanian S, Feng B, Xie B, Börnigen D, Dave UJ, Foster IT, Gilliam TC, Maltsev N. Lynx web services for annotations and systems analysis of multi-gene disorders. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W473-7. View in: PubMed

  10. Sulakhe D, Balasubramanian S, Xie B, Berrocal E, Feng B, Taylor A, Chitturi B, Dave U, Agam G, Xu J, Börnigen D, Dubchak I, Gilliam TC, Maltsev N. High-throughput translational medicine: challenges and solutions. Adv Exp Med Biol. 2014; 799:39-67. View in: PubMed

  11. Sulakhe D, Balasubramanian S, Xie B, Feng B, Taylor A, Wang S, Berrocal E, Dave U, Xu J, Börnigen D, Gilliam TC, Maltsev N. Lynx: a database and knowledge extraction engine for integrative medicine. Nucleic Acids Res. 2014 Jan; 42(Database issue):D1007-12. View in: PubMed

  12. Xu H, Cheng R, Juo SH, Liu J, Loth JE, Endicott J, Gilliam C, Baron M. Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q. Am J Med Genet B Neuropsychiatr Genet. 2011 Mar; 156(2):168-76. View in: PubMed

  13. Lajonchere CM. Changing the landscape of autism research: the autism genetic resource exchange. Neuron. 2010 Oct 21; 68(2):187-91. View in: PubMed

  14. Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM. Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Mol Psychiatry. 2010 Feb; 15(2):166-76. View in: PubMed

  15. Iossifov I, Zheng T, Baron M, Gilliam TC, Rzhetsky A. Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network. Genome Res. 2008 Jul; 18(7):1150-62. View in: PubMed

  16. Christian SL, Brune CW, Sudi J, Kumar RA, Liu S, Karamohamed S, Badner JA, Matsui S, Conroy J, McQuaid D, Gergel J, Hatchwell E, Gilliam TC, Gershon ES, Nowak NJ, Dobyns WB, Cook EH. Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder. Biol Psychiatry. 2008 Jun 15; 63(12):1111-7. View in: PubMed

  17. Ponder CA, Huded CP, Munoz MB, Gulden FO, Gilliam TC, Palmer AA. Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis. Behav Genet. 2008 May; 38(3):277-91. View in: PubMed

  18. Kumar RA, KaraMohamed S, Sudi J, Conrad DF, Brune C, Badner JA, Gilliam TC, Nowak NJ, Cook EH, Dobyns WB, Christian SL. Recurrent 16p11.2 microdeletions in autism. Hum Mol Genet. 2008 Feb 15; 17(4):628-38. View in: PubMed

  19. Ponder CA, Munoz M, Gilliam TC, Palmer AA. Genetic architecture of fear conditioning in chromosome substitution strains: relationship to measures of innate (unlearned) anxiety-like behavior. Mamm Genome. 2007 Apr; 18(4):221-8. View in: PubMed

  20. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimäki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M. Strong association of de novo copy number mutations with autism. Science. 2007 Apr 20; 316(5823):445-9. View in: PubMed

  21. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar; 39(3):319-28. View in: PubMed

  22. Ponder CA, Kliethermes CL, Drew MR, Muller J, Das K, Risbrough VB, Crabbe JC, Gilliam TC, Palmer AA. Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression. Genes Brain Behav. 2007 Nov; 6(8):736-49. View in: PubMed

  23. Martinez-Mir A, Zlotogorski A, Gordon D, Petukhova L, Mo J, Gilliam TC, Londono D, Haynes C, Ott J, Hordinsky M, Nanova K, Norris D, Price V, Duvic M, Christiano AM. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet. 2007 Feb; 80(2):316-28. View in: PubMed

  24. Xu H, Kellendonk CB, Simpson EH, Keilp JG, Bruder GE, Polan HJ, Kandel ER, Gilliam TC. DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability. Schizophr Res. 2007 Feb; 90(1-3):104-7. View in: PubMed

  25. Huster D, Finegold MJ, Morgan CT, Burkhead JL, Nixon R, Vanderwerf SM, Gilliam CT, Lutsenko S. Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol. 2006 Feb; 168(2):423-34. View in: PubMed

  26. Cheng R, Juo SH, Loth JE, Nee J, Iossifov I, Blumenthal R, Sharpe L, Kanyas K, Lerer B, Lilliston B, Smith M, Trautman K, Gilliam TC, Endicott J, Baron M. Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry. 2006 Mar; 11(3):252-60. View in: PubMed

  27. Yonan AL, Palmer AA, Gilliam TC. Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism. Psychiatr Genet. 2006 Feb; 16(1):31-4. View in: PubMed

  28. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. View in: PubMed

  29. Cheng R, Park N, Juo SH, Liu J, Loth JE, Endicott J, Gilliam TC, Baron M. Psychosis and the genetic spectrum of bipolar disorder: evidence from linkage analysis. Mol Psychiatry. 2006 Jan; 11(1):3-5. View in: PubMed

  30. Palmer AA, Verbitsky M, Suresh R, Kamens HM, Reed CL, Li N, Burkhart-Kasch S, McKinnon CS, Belknap JK, Gilliam TC, Phillips TJ. Gene expression differences in mice divergently selected for methamphetamine sensitivity. Mamm Genome. 2005 May; 16(5):291-305. View in: PubMed

  31. Bruder GE, Keilp JG, Xu H, Shikhman M, Schori E, Gorman JM, Gilliam TC. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry. 2005 Dec 01; 58(11):901-7. View in: PubMed

  32. Alarcón M, Yonan AL, Gilliam TC, Cantor RM, Geschwind DH. Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs. Mol Psychiatry. 2005 Aug; 10(8):747-57. View in: PubMed

  33. Park N, Cheng R, Juo SH, Liu J, Loth JE, Endicott J, Gilliam TC, Baron M. Absence of psychosis may influence linkage results for bipolar disorder. Mol Psychiatry. 2005 Mar; 10(3):235-7. View in: PubMed

  34. Krauthammer M, Kaufmann CA, Gilliam TC, Rzhetsky A. Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15148-53. View in: PubMed

  35. Stone JL, Merriman B, Cantor RM, Yonan AL, Gilliam TC, Geschwind DH, Nelson SF. Evidence for sex-specific risk alleles in autism spectrum disorder. Am J Hum Genet. 2004 Dec; 75(6):1117-23. View in: PubMed

  36. Tadin-Strapps M, Warburton D, Baumeister FA, Fischer SG, Yonan J, Gilliam TC, Christiano AM. Cloning of the breakpoints of a de novo inversion of chromosome 8, inv (8)(p11.2q23.1) in a patient with Ambras syndrome. Cytogenet Genome Res. 2004; 107(1-2):68-76. View in: PubMed

  37. Garcia Arocena D, Louis ED, Tassone F, Gilliam TC, Ottman R, Jacquemont S, Hagerman PJ. Screen for expanded FMR1 alleles in patients with essential tremor. Mov Disord. 2004 Aug; 19(8):930-3. View in: PubMed

  38. Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Månér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M. Large-scale copy number polymorphism in the human genome. Science. 2004 Jul 23; 305(5683):525-8. View in: PubMed

  39. Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B, Nee J, Grunn A, Kanyas K, Lerer B, Endicott J, Gilliam TC, Baron M. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry. 2004 Dec; 9(12):1091-9. View in: PubMed

  40. Morabia A, Ross BM, Costanza MC, Cayanis E, Flaherty MS, Alvin GB, Das K, James R, Yang AS, Evagrafov O, Gilliam TC. Population-based study of SR-BI genetic variation and lipid profile. Atherosclerosis. 2004 Jul; 175(1):159-68. View in: PubMed

  41. Verbitsky M, Yonan AL, Malleret G, Kandel ER, Gilliam TC, Pavlidis P. Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. Learn Mem. 2004 May-Jun; 11(3):253-60. View in: PubMed

  42. Ottman R, Winawer MR, Kalachikov S, Barker-Cummings C, Gilliam TC, Pedley TA, Hauser WA. LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology. 2004 Apr 13; 62(7):1120-6. View in: PubMed

  43. Martinez-Mir A, Zlotogorski A, Londono D, Gordon D, Grunn A, Uribe E, Horev L, Ruiz IM, Davalos NO, Alayan O, Liu J, Gilliam TC, Salas-Alanis JC, Christiano AM. Identification of a locus for type I punctate palmoplantar keratoderma on chromosome 15q22-q24. J Med Genet. 2003 Dec; 40(12):872-8. View in: PubMed

  44. Kim S, Ruparel HD, Gilliam TC, Ju J. Digital genotyping using molecular affinity and mass spectrometry. Nat Rev Genet. 2003 Dec; 4(12):1001-8. View in: PubMed

  45. Yonan AL, Palmer AA, Smith KC, Feldman I, Lee HK, Yonan JM, Fischer SG, Pavlidis P, Gilliam TC. Bioinformatic analysis of autism positional candidate genes using biological databases and computational gene network prediction. Genes Brain Behav. 2003 Oct; 2(5):303-20. View in: PubMed

  46. Yonan AL, Alarcón M, Cheng R, Magnusson PK, Spence SJ, Palmer AA, Grunn A, Juo SH, Terwilliger JD, Liu J, Cantor RM, Geschwind DH, Gilliam TC. A genomewide screen of 345 families for autism-susceptibility loci. Am J Hum Genet. 2003 Oct; 73(4):886-97. View in: PubMed

  47. Morabia A, Cayanis E, Costanza MC, Ross BM, Flaherty MS, Alvin GB, Das K, Gilliam TC. Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. Hum Mol Genet. 2003 Nov 01; 12(21):2733-43. View in: PubMed

  48. Chen A, Muzzio IA, Malleret G, Bartsch D, Verbitsky M, Pavlidis P, Yonan AL, Vronskaya S, Grody MB, Cepeda I, Gilliam TC, Kandel ER. Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron. 2003 Aug 14; 39(4):655-69. View in: PubMed

  49. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lönnqvist J, Nöthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet. 2003 Jul; 73(1):49-62. View in: PubMed

  50. Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CA, Morris RJ, Panteleyev AA, Nguyen VT, Christiano AM. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell. 2003 Apr 18; 113(2):249-60. View in: PubMed

  51. Morabia A, Cayanis E, Costanza MC, Ross BM, Bernstein MS, Flaherty MS, Alvin GB, Das K, Morris MA, Penchaszadeh GK, Zhang P, Gilliam TC. Association between lipoprotein lipase (LPL) gene and blood lipids: a common variant for a common trait? Genet Epidemiol. 2003 May; 24(4):309-21. View in: PubMed

  52. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Knowles JA, Ott J, Gilliam TC, Baron M. Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry. 2003 Mar; 8(3):333-42. View in: PubMed

  53. Zhang P, Sheng H, Morabia A, Gilliam TC. Optimal step length EM algorithm (OSLEM) for the estimation of haplotype frequency and its application in lipoprotein lipase genotyping. BMC Bioinformatics. 2003 Jan 15; 4:3. View in: PubMed

  54. Winawer MR, Martinelli Boneschi F, Barker-Cummings C, Lee JH, Liu J, Mekios C, Gilliam TC, Pedley TA, Hauser WA, Ottman R. Four new families with autosomal dominant partial epilepsy with auditory features: clinical description and linkage to chromosome 10q24. Epilepsia. 2002 Jan; 43(1):60-7. View in: PubMed

  55. Martinez-Mir A, Liu J, Gordon D, Weiner MS, Ahmad W, Fine JD, Ott J, Gilliam TC, Christiano AM. EB simplex superficialis resulting from a mutation in the type VII collagen gene. J Invest Dermatol. 2002 Mar; 118(3):547-9. View in: PubMed

  56. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, Martinelli Boneschi F, Choi C, Morozov P, Das K, Teplitskaya E, Yu A, Cayanis E, Penchaszadeh G, Kottmann AH, Pedley TA, Hauser WA, Ottman R, Gilliam TC. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet. 2002 Mar; 30(3):335-41. View in: PubMed

  57. Alarcón M, Cantor RM, Liu J, Gilliam TC, Geschwind DH. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. Am J Hum Genet. 2002 Jan; 70(1):60-71. View in: PubMed

  58. Liu J, Juo SH, Holopainen P, Terwilliger J, Tong X, Grunn A, Brito M, Green P, Mustalahti K, Mäki M, Gilliam TC, Partanen J. Genomewide linkage analysis of celiac disease in Finnish families. Am J Hum Genet. 2002 Jan; 70(1):51-9. View in: PubMed

  59. Liu J, Nyholt DR, Magnussen P, Parano E, Pavone P, Geschwind D, Lord C, Iversen P, Hoh J, Ott J, Gilliam TC. A genomewide screen for autism susceptibility loci. Am J Hum Genet. 2001 Aug; 69(2):327-40. View in: PubMed

  60. Liu J, Juo SH, Terwilliger JD, Grunn A, Tong X, Brito M, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Gilliam TC, Baron M. A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22. Am J Med Genet. 2001 Mar 08; 105(2):189-94. View in: PubMed

  61. Ranta S, Zhang Y, Ross B, Takkunen E, Hirvasniemi A, de la Chapelle A, Gilliam TC, Lehesjoki AE. Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation. Eur J Hum Genet. 2000 May; 8(5):381-4. View in: PubMed

  62. Aita VM, Ahmad W, Panteleyev AA, Kozlowska U, Kozlowska A, Gilliam TC, Jablonska S, Christiano AM. A novel missense mutation (C622G) in the zinc-finger domain of the human hairless gene associated with congenital atrichia with papular lesions. Exp Dermatol. 2000 Apr; 9(2):157-62. View in: PubMed

  63. Aita VM, Christiano AM, Gilliam TC. Mapping complex traits in diseases of the hair and skin. Exp Dermatol. 1999 Dec; 8(6):439-52. View in: PubMed

  64. Ranta S, Zhang Y, Ross B, Lonka L, Takkunen E, Messer A, Sharp J, Wheeler R, Kusumi K, Mole S, Liu W, Soares MB, Bonaldo MF, Hirvasniemi A, de la Chapelle A, Gilliam TC, Lehesjoki AE. The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8. Nat Genet. 1999 Oct; 23(2):233-6. View in: PubMed

  65. Larin D, Mekios C, Das K, Ross B, Yang AS, Gilliam TC. Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p. J Biol Chem. 1999 Oct 01; 274(40):28497-504. View in: PubMed

  66. Buiakova OI, Xu J, Lutsenko S, Zeitlin S, Das K, Das S, Ross BM, Mekios C, Scheinberg IH, Gilliam TC. Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet. 1999 Sep; 8(9):1665-71. View in: PubMed

  67. Lewis CA, Batlle IR, Batlle KG, Banerjee P, Cideciyan AV, Huang J, Alemán TS, Huang Y, Ott J, Gilliam TC, Knowles JA, Jacobson SG. Tubby-like protein 1 homozygous splice-site mutation causes early-onset severe retinal degeneration. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):2106-14. View in: PubMed

  68. Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics. 1999 Jul 01; 59(1):59-65. View in: PubMed

  69. Aita VM, Liu J, Knowles JA, Terwilliger JD, Baltazar R, Grunn A, Loth JE, Kanyas K, Lerer B, Endicott J, Wang Z, Penchaszadeh G, Gilliam TC, Baron M. A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus. Am J Hum Genet. 1999 Jan; 64(1):210-7. View in: PubMed

  70. Gavrilov DK, Shi X, Das K, Gilliam TC, Wang CH. Differential SMN2 expression associated with SMA severity. Nat Genet. 1998 Nov; 20(3):230-1. View in: PubMed

  71. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM, Rassnick H, Preud'homme-Rivelli X, Austin T, Cunjak J, Mick S, Fine LD, Woodley KA, Das K, Maier W, Adams PB, Freimer NB, Klein DF, Gilliam TC. Results of a genome-wide genetic screen for panic disorder. Am J Med Genet. 1998 Mar 28; 81(2):139-47. View in: PubMed

  72. Frucht S, Sun D, Schiff N, Eidelberg D, Gilliam TC. Arm tremor secondary to Wilson's disease. Mov Disord. 1998 Mar; 13(2):351-3. View in: PubMed

  73. Knowles JA, Rao PA, Cox-Matise T, Loth JE, de Jesus GM, Levine L, Das K, Penchaszadeh GK, Alexander JR, Lerer B, Endicott J, Ott J, Gilliam TC, Baron M. No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees. Am J Hum Genet. 1998 Apr; 62(4):916-24. View in: PubMed

  74. Banerjee P, Lewis CA, Kleyn PW, Shugart YY, Ross BM, Penchaszadeh GK, Ott J, Jacobson SG, Gilliam TC, Knowles JA. Homozygosity and physical mapping of the autosomal recessive retinitis pigmentosa locus (RP14) on chromosome 6p21.3. Genomics. 1998 Mar 01; 48(2):171-7. View in: PubMed

  75. Banerjee P, Kleyn PW, Knowles JA, Lewis CA, Ross BM, Parano E, Kovats SG, Lee JJ, Penchaszadeh GK, Ott J, Jacobson SG, Gilliam TC. TULP1 mutation in two extended Dominican kindreds with autosomal recessive retinitis pigmentosa. Nat Genet. 1998 Feb; 18(2):177-9. View in: PubMed

  76. Lutsenko S, Petrukhin K, Gilliam TC, Kaplan JH. Heterologous expression of the metal-binding domains of human copper-transporting ATPases (P1-ATPases). Ann N Y Acad Sci. 1997 Nov 03; 834:155-7. View in: PubMed

  77. Ranta S, Lehesjoki AE, de Fatima Bonaldo M, Knowles JA, Hirvasniemi A, Ross B, de Jong PJ, Soares MB, de la Chapelle A, Gilliam TC. High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p. Genome Res. 1997 Sep; 7(9):887-96. View in: PubMed

  78. Shah AB, Chernov I, Zhang HT, Ross BM, Das K, Lutsenko S, Parano E, Pavone L, Evgrafov O, Ivanova-Smolenskaya IA, Annerén G, Westermark K, Urrutia FH, Penchaszadeh GK, Sternlieb I, Scheinberg IH, Gilliam TC, Petrukhin K. Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotype-phenotype correlation, and functional analyses. Am J Hum Genet. 1997 Aug; 61(2):317-28. View in: PubMed

  79. Yang XL, Miura N, Kawarada Y, Terada K, Petrukhin K, Gilliam T, Sugiyama T. Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments. Biochem J. 1997 Sep 15; 326 ( Pt 3):897-902. View in: PubMed

  80. Wang CH, Carter TA, Das K, Xu J, Ross BM, Penchaszadeh GK, Gilliam TC. Extensive DNA deletion associated with severe disease alleles on spinal muscular atrophy homologues. Ann Neurol. 1997 Jul; 42(1):41-9. View in: PubMed

  81. Carter TA, Bönnemann CG, Wang CH, Obici S, Parano E, De Fatima Bonaldo M, Ross BM, Penchaszadeh GK, Mackenzie A, Soares MB, Kunkel LM, Gilliam TC. A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions. Hum Mol Genet. 1997 Feb; 6(2):229-36. View in: PubMed

  82. Ferenci P, Gilliam TC, Gitlin JD, Packman S, Schilsky ML, Sokol RJ, Sternlieb I. An international symposium on Wilson's and Menkes' diseases. Hepatology. 1996 Oct; 24(4):952-8. View in: PubMed

  83. Wang CH, Xu J, Carter TA, Ross BM, Dominski MK, Bellcross CA, Penchaszadeh GK, Munsat TL, Gilliam TC. Characterization of survival motor neuron (SMNT) gene deletions in asymptomatic carriers of spinal muscular atrophy. Hum Mol Genet. 1996 Mar; 5(3):359-65. View in: PubMed

  84. Ranta S, Lehesjoki AE, Hirvasniemi A, Weissenbach J, Ross B, Leal SM, de la Chapelle A, Gilliam TC. Genetic and physical mapping of the progressive epilepsy with mental retardation (EPMR) locus on chromosome 8p. Genome Res. 1996 May; 6(5):351-60. View in: PubMed

  85. Wilhelmsen KC, Blake DM, Lynch T, Mabutas J, De Vera M, Neystat M, Bernstein M, Hirano M, Gilliam TC, Murphy PL, Sola MD, Bonilla E, Schotland DL, Hays AP, Rowland LP. Chromosome 12-linked autosomal dominant scapuloperoneal muscular dystrophy. Ann Neurol. 1996 Apr; 39(4):507-20. View in: PubMed

  86. Soares VM, Brzustowicz LM, Kleyn PW, Knowles JA, Palmer DA, Asokan S, Penchaszadeh GK, Munsat TL, Gilliam TC. Refinement of the spinal muscular atrophy locus to the interval between D5S435 and MAP1B. Genomics. 1993 Feb; 15(2):365-71. View in: PubMed

  87. Petrukhin KE, Speer MC, Cayanis E, Bonaldo MF, Tantravahi U, Soares MB, Fischer SG, Warburton D, Gilliam TC, Ott J. A microsatellite genetic linkage map of human chromosome 13. Genomics. 1993 Jan; 15(1):76-85. View in: PubMed

  88. Thompson TG, Morrison KE, Kleyn P, Bengtsson U, Gilliam TC, Davies KE, Wasmuth JJ, McPherson JD. High resolution physical map of the region surrounding the spinal muscular atrophy gene. Hum Mol Genet. 1993 Aug; 2(8):1169-76. View in: PubMed

  89. Nygaard TG, Wilhelmsen KC, Risch NJ, Brown DL, Trugman JM, Gilliam TC, Fahn S, Weeks DE. Linkage mapping of dopa-responsive dystonia (DRD) to chromosome 14q. Nat Genet. 1993 Dec; 5(4):386-91. View in: PubMed

  90. Kleyn PW, Gilliam TC. Progress toward cloning of the gene responsible for childhood spinal muscular atrophy. Semin Neurol. 1993 Sep; 13(3):276-82. View in: PubMed

  91. Brzustowicz LM, Mérette C, Xie X, Townsend L, Gilliam TC, Ott J. Molecular and statistical approaches to the detection and correction of errors in genotype databases. Am J Hum Genet. 1993 Nov; 53(5):1137-45. View in: PubMed

  92. Le Beau MM, Overhauser J, Straub RE, Silverman G, Gilliam TC, Ott J, O'Connell P, Francke U, Geurts van Kessel A. Report of the first international workshop on human chromosome 18 mapping. Cytogenet Cell Genet. 1993; 63(2):78-96. View in: PubMed

  93. Locke PA, MacDonald ME, Srinidhi J, Gilliam TC, Tanzi RE, Conneally PM, Wexler NS, Haines JL, Gusella JF. A genetic linkage map of the chromosome 4 short arm. Somat Cell Mol Genet. 1993 Jan; 19(1):95-101. View in: PubMed

  94. Straub RE, Speer MC, Luo Y, Rojas K, Overhauser J, Ott J, Gilliam TC. A microsatellite genetic linkage map of human chromosome 18. Genomics. 1993 Jan; 15(1):48-56. View in: PubMed

  95. Mérette C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Munnich A, Pericak-Vance MA, Siddique T, Voosen B, et al. An investigation of genetic heterogeneity and linkage disequilibrium in 161 families with spinal muscular atrophy. Genomics. 1994 May 01; 21(1):27-33. View in: PubMed

  96. Knowles JA, Shugart Y, Banerjee P, Gilliam TC, Lewis CA, Jacobson SG, Ott J. Identification of a locus, distinct from RDS-peripherin, for autosomal recessive retinitis pigmentosa on chromosome 6p. Hum Mol Genet. 1994 Aug; 3(8):1401-3. View in: PubMed

  97. Baron M, Straub RE, Lehner T, Endicott J, Ott J, Gilliam TC, Lerer B. Bipolar disorder and linkage to Xq28. Nat Genet. 1994 Aug; 7(4):461-2. View in: PubMed

  98. Brzustowicz LM, Mérette C, Kleyn PW, Lehner T, Castilla LH, Penchaszadeh GK, Das K, Munsat TL, Ott J, Gilliam TC. Assessment of nonallelic genetic heterogeneity of chronic (type II and III) spinal muscular atrophy. Hum Hered. 1993 Nov-Dec; 43(6):380-7. View in: PubMed

  99. Petrukhin K, Gilliam TC. Genetic disorders of copper metabolism. Curr Opin Pediatr. 1994 Dec; 6(6):698-701. View in: PubMed

  100. Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC. Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions. Hum Mol Genet. 1994 Sep; 3(9):1647-56. View in: PubMed

  101. Brzustowicz LM, Wang CH, Matseoane D, Kleyn PW, Vitale E, Das K, Penchaszadeh GK, Munsat TL, Hausmanowa-Petrusewicz I, Gilliam TC. Linkage disequilibrium and haplotype analysis among Polish families with spinal muscular atrophy. Am J Hum Genet. 1995 Jan; 56(1):210-5. View in: PubMed

  102. Huang TH, Yeh PL, Martin MB, Straub RE, Gilliam TC, Caldwell CW, Skibba JL. Genetic alterations of microsatellites on chromosome 18 in human breast carcinoma. Diagn Mol Pathol. 1995 Mar; 4(1):66-72. View in: PubMed

  103. Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM. Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3702-6. View in: PubMed

  104. Boylan KB, Cornblath DR, Glass JD, Alderson K, Kuncl RW, Kleyn PW, Gilliam TC. Autosomal dominant distal spinal muscular atrophy in four generations. Neurology. 1995 Apr; 45(4):699-704. View in: PubMed

  105. Shugart YY, Banerjee P, Knowles JA, Lewis CA, Jacobson SG, Matise TC, Penchaszadeh G, Gilliam TC, Ott J. Fine genetic mapping of a gene for autosomal recessive retinitis pigmentosa on chromosome 6p21. Am J Hum Genet. 1995 Aug; 57(2):499-502. View in: PubMed

  106. Gilliam TC. Is the spinal muscular atrophy gene found? Nat Med. 1995 Feb; 1(2):124-7. View in: PubMed

  107. Williamson R, Davies KE, Donald J, Gilliam C, Wallis S, Humphries S. The implications of genetic variation in human pathology. Biochem Soc Symp. 1984; 49:183-8. View in: PubMed

  108. Robbins J, Freyer GA, Chisholm D, Gilliam TC. Isolation of multiple genomic sequences coding for chicken myosin heavy chain protein. J Biol Chem. 1982 Jan 10; 257(1):549-56. View in: PubMed

  109. Davies KE, Gilliam TC, Williamson R. Cystic fibrosis is not caused by a defect in the gene coding for human complement C3. Mol Biol Med. 1983 Sep; 1(2):185-90. View in: PubMed

  110. Gilliam TC, Scambler P, Robbins T, Ingle C, Williamson R, Davies KE. The positions of three restriction fragment length polymorphisms on chromosome 4 relative to known genetic markers. Hum Genet. 1984; 68(2):154-8. View in: PubMed

  111. Gusella JF, Tanzi RE, Anderson MA, Hobbs W, Gibbons K, Raschtchian R, Gilliam TC, Wallace MR, Wexler NS, Conneally PM. DNA markers for nervous system diseases. Science. 1984 Sep 21; 225(4668):1320-6. View in: PubMed

  112. Seizinger BR, Tanzi RE, Gilliam TC, Bader JL, Parry DM, Spence MA, Marazita ML, Gibbons K, Hobbs W, Gusella JF. Genetic linkage analysis of neurofibromatosis with DNA markers. Ann N Y Acad Sci. 1986; 486:304-10. View in: PubMed

  113. Scambler P, Robbins T, Gilliam C, Boylston A, Tippett P, Williamson R, Davies KE. Linkage studies between polymorphic markers on chromosome 4 and cystic fibrosis. Hum Genet. 1985; 69(3):250-4. View in: PubMed

  114. Gusella JA, Gilliam TC, MacDonald ME, Cheng SV, Tanzi RE. Molecular genetics of human chromosome 4. J Med Genet. 1986 Jun; 23(3):193-9. View in: PubMed

  115. Whaley WL, Michiels F, MacDonald ME, Romano D, Zimmer M, Smith B, Leavitt J, Bucan M, Haines JL, Gilliam TC, et al. Mapping of D4S98/S114/S113 confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4. Nucleic Acids Res. 1988 Dec 23; 16(24):11769-80. View in: PubMed

  116. Richards JE, Gilliam TC, Cole JL, Drumm ML, Wasmuth JJ, Gusella JF, Collins FS. Chromosome jumping from D4S10 (G8) toward the Huntington disease gene. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6437-41. View in: PubMed

  117. Murray JC, Buetow KH, Smith M, Carlock L, Chakravarti A, Ferrell RF, Gedamu L, Gilliam C, Shiang R, DeHaven CR. Pairwise linkage analysis of 11 loci on human chromosome 4. Am J Hum Genet. 1988 Mar; 42(3):490-7. View in: PubMed

  118. Gilliam TC, Gusella JF, Lehrach H. Molecular genetic strategies to investigate Huntington's disease. Adv Neurol. 1988; 48:17-29. View in: PubMed

  119. Gilliam TC, Bucan M, MacDonald ME, Zimmer M, Haines JL, Cheng SV, Pohl TM, Meyers RH, Whaley WL, Allitto BA, et al. A DNA segment encoding two genes very tightly linked to Huntington's disease. Science. 1987 Nov 13; 238(4829):950-2. View in: PubMed

  120. MacDonald ME, Anderson MA, Gilliam TC, Tranejaerg L, Carpenter NJ, Magenis E, Hayden MR, Healey ST, Bonner TI, Gusella JF. A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene. Genomics. 1987 Sep; 1(1):29-34. View in: PubMed

  121. Blanché H, Zunec R, Gilliam C, Hartley D, Williamson R, Dausset J, Cann HM. A human anonymous low copy number clone, 4c11 (D6S4), localized to 6p12-6p21, detects 2 RFLPs, one of which is moderately polymorphic. Nucleic Acids Res. 1987 Jul 24; 15(14):5902. View in: PubMed

  122. Gilliam TC, Tanzi RE, Haines JL, Bonner TI, Faryniarz AG, Hobbs WJ, MacDonald ME, Cheng SV, Folstein SE, Conneally PM, et al. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell. 1987 Aug 14; 50(4):565-71. View in: PubMed

  123. Gusella JF, Gilliam TC, Tanzi RE, MacDonald ME, Cheng SV, Wallace M, Haines J, Conneally PM, Wexler NS. Molecular genetics of Huntington's disease. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:359-64. View in: PubMed

  124. Gilliam TC, Healey ST, MacDonald ME, Stewart GD, Wasmuth JJ, Tanzi RE, Roy JC, Gusella JF. Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Res. 1987 Feb 25; 15(4):1445-58. View in: PubMed

  125. Kaufmann CA, DeLisi LE, Lehner T, Gilliam TC. Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q. Schizophr Bull. 1989; 15(3):441-52. View in: PubMed

  126. Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ. Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics. 1989 Nov; 5(4):940-4. View in: PubMed

  127. Youngman S, Sarfarazi M, Bucan M, MacDonald M, Smith B, Zimmer M, Gilliam C, Frischauf AM, Wasmuth JJ, Gusella JF, et al. A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene. Genomics. 1989 Nov; 5(4):802-9. View in: PubMed

  128. Weeks DE, Brzustowicz L, Squires-Wheeler E, Cornblatt B, Lehner T, Stefanovich M, Bassett A, Gilliam TC, Ott J, Erlenmeyer-Kimling L. Report of a workshop on genetic linkage studies in schizophrenia. Schizophr Bull. 1990; 16(4):673-86. View in: PubMed

  129. Gilliam TC, Brzustowicz LM, Castilla LH, Lehner T, Penchaszadeh GK, Daniels RJ, Byth BC, Knowles J, Hislop JE, Shapira Y, et al. Genetic homogeneity between acute and chronic forms of spinal muscular atrophy. Nature. 1990 Jun 28; 345(6278):823-5. View in: PubMed

  130. Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM. Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7873-6. View in: PubMed

  131. Brzustowicz LM, Wilhelmsen KC, Gilliam TC. Genetic analysis of childhood-onset spinal muscular atrophy. Adv Neurol. 1991; 56:181-7. View in: PubMed

  132. Kleyn PW, Brzustowicz LM, Wilhelmsen KC, Freimer NB, Miller JM, Munsat TL, Gilliam TC. Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus. Neurology. 1991 Sep; 41(9):1418-22. View in: PubMed

  133. Wilhelmsen KC, Weeks DE, Nygaard TG, Moskowitz CB, Rosales RL, dela Paz DC, Sobrevega EE, Fahn S, Gilliam TC. Genetic mapping of "Lubag" (X-linked dystonia-parkinsonism) in a Filipino kindred to the pericentromeric region of the X chromosome. Ann Neurol. 1991 Feb; 29(2):124-31. View in: PubMed

  134. Consalez GG, Stayton CL, Freimer NB, Goonewardena P, Brown WT, Gilliam TC, Warren ST. Isolation and characterization of a highly polymorphic human locus (DXS455) in proximal Xq28. Genomics. 1992 Apr; 12(4):710-4. View in: PubMed

  135. Rojas K, Straub RE, Kurtz A, Feder M, Mewar R, Gilliam TC, Overhauser J. Identification and localization of microsatellite markers covering human chromosome 18. Genomics. 1992 Dec; 14(4):1095-7. View in: PubMed

  136. Knowles JA, Vieland VJ, Gilliam TC. Perils of gene mapping with microsatellite markers. Am J Hum Genet. 1992 Oct; 51(4):905-9. View in: PubMed

  137. Gilliam TC. Mapping psychiatric disease genes: impact of new molecular strategies. J Psychiatr Res. 1992 Oct; 26(4):309-26. View in: PubMed

  138. Ben Othmane K, Ben Hamida M, Pericak-Vance MA, Ben Hamida C, Blel S, Carter SC, Bowcock AM, Petruhkin K, Gilliam TC, Roses AD, et al. Linkage of Tunisian autosomal recessive Duchenne-like muscular dystrophy to the pericentromeric region of chromosome 13q. Nat Genet. 1992 Dec; 2(4):315-7. View in: PubMed

  139. Petrukhin KE, Modyanov NN, Gilliam TC. Dinucleotide repeat polymorphism at the D4S251 locus. Hum Mol Genet. 1992 Aug; 1(5):349. View in: PubMed

  140. Petrukhin KE, Gilliam TC. Dinucleotide repeat polymorphism at the D19S206 locus. Hum Mol Genet. 1992 Sep; 1(6):454. View in: PubMed

  141. Petrukhin KE, Gilliam TC. Dinucleotide repeat polymorphism at the D1S182 locus. Hum Mol Genet. 1992 Sep; 1(6):454. View in: PubMed

  142. S. Lutsenko, K Petrukhin, MJ Cooper, TC Gilliam, and J Kaplan. . N-terminal domains of human Cu-transporting ATPases (the Wilson’s and Menkes disease proteins) bind Cu selectively in vivo and in vitro with stoichiometry of one Cu per metal-binding repeat. Journal of Biological Chemistry. 1997; 272:18939-18944.::::

  143. 44. K Petrukhin, SG Fischer, M Pirastu, RE Tanzi, I Chernov, M Devoto, LM Brzustowicz, E Cayanis, E Vitale, J Russo, D Matseoane, B Boukhgalter, AL Figlis, J Lolidihnos, A Cao I Sternlieb , O Evgrafov, E Parano, L Pavone, D Warburton, J Ott, GK Penchaszadeh, IH Scheinberg, and TC Gilliam. . Physical mapping, cloning, and genetic characterization of the Wilson disease locus. Nature Genetics. 1993; 5:338-343.::::

  144. 19. Brzustowicz LB., Lehner T, Castilla L, Penchaszadeh GK, Wilhelmsen K, Daniels R, Davies KE, Leppert M, Ziter F, Wood D, Dubowits V, Zerres K, Hausmanowa-Petrusewicz I, Ott J, Munsat T, and Gilliam TC . Genetic mapping of chronic childhood-onset Spinal Muscular Atrophy to Chromosome 5q11.2-13.3. Nature. 1990; 344:540-541.::::

  145. D'Souza, M., Sulakhe, D., Wang, S., Xie, B., Hashemifar, S., Taylor, A., Dubchak, I., Conrad Gilliam, T., Maltsev, N.

    . Strategic Integration of Multiple Bioinformatics Resources for System Level Analysis of Biological Networks. Methods Mol Biol. 2017; 1613:85-89.::::

  146. Parano, E,. Falcidia E, Grillo A, Pavone P, Cutuli N, Takabayashi H, Trifiletti RR, and TC Gilliam. . Noninvasive prenatal diagnosis of chromosomal anueploidies by isolation and analysis of fetal cells from maternal blood. Amer. J. of Med. Genet. 2001; 101:262-267.::::

  147. RE Tanzi, K Petrukhin, I Chernov, JL Pellequer, W. Wasco, B Ross, DM Romano, LM Brzustowicz, M Devoto, J Peppercorn, AI Bush, I Sternlieb, M Pirastu, JF Gusella, O Evgrafov, GK Penchaszadeh, B Honig, IS Edelman, MB Soares, IH Scheinberg, and TC Gilliam. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes Disease gene. Nature Genetics. 1993; 5:344-350.::::

  148. Huster, D.
    Finegold, M. J.
    Morgan, C. T.
    Burkhead, J. L.
    Nixon, R.
    Vanderwerf, S. M.
    Gilliam, C. T.
    Lutsenko, S. Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol. 2006; 168(2):423-434.::::

  149. Kara, S.
    Pirela-Morillo, G. A.
    Gilliam, C. T.
    Wilson, G. D. Identification of novel susceptibility genes associated with seven autoimmune disorders using whole genome molecular interaction networks. J Autoimmun. 2019; 97:48-58.::::