Maanasa Raghavan

Assistant Professor
Websites
Research Summary
My group's research interests span questions and applications in multiple fields, including population genetics/genomics, anthropology, archaeology, and medical genetics. The big question driving our research is: ‘How have demographic, cultural, and environmental factors contributed over time to shaping the genetic profiles of present-day human populations?’ In order to address specific research questions embedded within this overarching goal, we use a combined approach that brings together genome-scale data from present-day and ancient humans and their biotic environment, especially domesticates and pathogens. Through the implementation of multiple complementary projects set within the context of South Asian and indigenous American populations, our research will ultimately contribute towards the understanding of the evolutionary mechanisms that underlie adaptations and diseases among human populations.
Keywords
Population and Evolutionary Genetics, Ancient DNA, Genomics, Human Evolution
Education
  • University of Copenhagen, Denmark, PhD Paleogenomics (ancient DNA) 12/2011
  • University of Oxford, UK, MSc Archaeological Sciences 09/2007
  • University of Toronto, Canada, BSc (Hons) Molecular Biology 06/2006
Biosciences Graduate Program Association
Awards & Honors
  • 2018 - 2023 Neubauer Family Assistant Professors Program University of Chicago
Publications
  1. Raghavan M, Schroeder H, Malaspinas AS. An Ancient Genome from the Indus Valley Civilization. Cell. 2019 Oct 17; 179(3):586-588. View in: PubMed

  2. Seersholm FV, Pedersen MW, Søe MJ, Shokry H, Mak SS, Ruter A, Raghavan M, Fitzhugh W, Kjær KH, Willerslev E, Meldgaard M, Kapel CM, Hansen AJ. DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago. Nat Commun. 2016 11 08; 7:13389. View in: PubMed

  3. Raghavan M, Steinrücken M, Harris K, Schiffels S, Rasmussen S, DeGiorgio M, Albrechtsen A, Valdiosera C, Ávila-Arcos MC, Malaspinas AS, Eriksson A, Moltke I, Metspalu M, Homburger JR, Wall J, Cornejo OE, Moreno-Mayar JV, Korneliussen TS, Pierre T, Rasmussen M, Campos PF, de Barros Damgaard P, Allentoft ME, Lindo J, Metspalu E, Rodríguez-Varela R, Mansilla J, Henrickson C, Seguin-Orlando A, Malmström H, Stafford T, Shringarpure SS, Moreno-Estrada A, Karmin M, Tambets K, Bergström A, Xue Y, Warmuth V, Friend AD, Singarayer J, Valdes P, Balloux F, Leboreiro I, Vera JL, Rangel-Villalobos H, Pettener D, Luiselli D, Davis LG, Heyer E, Zollikofer CPE, Ponce de León MS, Smith CI, Grimes V, Pike KA, Deal M, Fuller BT, Arriaza B, Standen V, Luz MF, Ricaut F, Guidon N, Osipova L, Voevoda MI, Posukh OL, Balanovsky O, Lavryashina M, Bogunov Y, Khusnutdinova E, Gubina M, Balanovska E, Fedorova S, Litvinov S, Malyarchuk B, Derenko M, Mosher MJ, Archer D, Cybulski J, Petzelt B, Mitchell J, Worl R, Norman PJ, Parham P, Kemp BM, Kivisild T, Tyler-Smith C, Sandhu MS, Crawford M, Villems R, Smith DG, Waters MR, Goebel T, Johnson JR, Malhi RS, Jakobsson M, Meltzer DJ, Manica A, Durbin R, Bustamante CD, Song YS, Nielsen R, Willerslev E. POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science. 2015 Aug 21; 349(6250):aab3884. View in: PubMed

  4. Schubert M, Jónsson H, Chang D, Der Sarkissian C, Ermini L, Ginolhac A, Albrechtsen A, Dupanloup I, Foucal A, Petersen B, Fumagalli M, Raghavan M, Seguin-Orlando A, Korneliussen TS, Velazquez AM, Stenderup J, Hoover CA, Rubin CJ, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, MacHugh DE, Kalbfleisch T, MacLeod JN, Rubin EM, Sicheritz-Ponten T, Andersson L, Hofreiter M, Marques-Bonet T, Gilbert MT, Nielsen R, Excoffier L, Willerslev E, Shapiro B, Orlando L. Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):E5661-9. View in: PubMed

  5. Der Sarkissian C, Allentoft ME, Ávila-Arcos MC, Barnett R, Campos PF, Cappellini E, Ermini L, Fernández R, da Fonseca R, Ginolhac A, Hansen AJ, Jónsson H, Korneliussen T, Margaryan A, Martin MD, Moreno-Mayar JV, Raghavan M, Rasmussen M, Velasco MS, Schroeder H, Schubert M, Seguin-Orlando A, Wales N, Gilbert MT, Willerslev E, Orlando L. Ancient genomics. Philos Trans R Soc Lond B Biol Sci. 2015 Jan 19; 370(1660):20130387. View in: PubMed

  6. Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, Brunak S, Sicheritz-Ponten T, Hodges E, Hannon GJ, Orlando L, Price TD, Jensen JD, Nielsen R, Heinemeier J, Olsen J, Rodrigues-Carvalho C, Lahr MM, Neves WA, Kayser M, Higham T, Stoneking M, Pena SD, Willerslev E. Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil. Curr Biol. 2014 Nov 03; 24(21):R1035-7. View in: PubMed

  7. Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G, Pagani L, Lawson DJ, Antão T, Vicente M, Mitt M, DeGiorgio M, Faltyskova Z, Xue Y, Ayub Q, Szpak M, Mägi R, Eriksson A, Manica A, Raghavan M, Rasmussen M, Rasmussen S, Willerslev E, Vidal-Puig A, Tyler-Smith C, Villems R, Nielsen R, Metspalu M, Malyarchuk B, Derenko M, Kivisild T. A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. Am J Hum Genet. 2014 11 06; 95(5):584-589. View in: PubMed

  8. Juras A, Dabert M, Kushniarevich A, Malmström H, Raghavan M, Kosicki JZ, Metspalu E, Willerslev E, Piontek J. Ancient DNA reveals matrilineal continuity in present-day Poland over the last two millennia. PLoS One. 2014; 9(10):e110839. View in: PubMed

  9. Raghavan M, DeGiorgio M, Albrechtsen A, Moltke I, Skoglund P, Korneliussen TS, Grønnow B, Appelt M, Gulløv HC, Friesen TM, Fitzhugh W, Malmström H, Rasmussen S, Olsen J, Melchior L, Fuller BT, Fahrni SM, Stafford T, Grimes V, Renouf MA, Cybulski J, Lynnerup N, Lahr MM, Britton K, Knecht R, Arneborg J, Metspalu M, Cornejo OE, Malaspinas AS, Wang Y, Rasmussen M, Raghavan V, Hansen TV, Khusnutdinova E, Pierre T, Dneprovsky K, Andreasen C, Lange H, Hayes MG, Coltrain J, Spitsyn VA, Götherström A, Orlando L, Kivisild T, Villems R, Crawford MH, Nielsen FC, Dissing J, Heinemeier J, Meldgaard M, Bustamante C, O'Rourke DH, Jakobsson M, Gilbert MT, Nielsen R, Willerslev E. The genetic prehistory of the New World Arctic. Science. 2014 Aug 29; 345(6200):1255832. View in: PubMed

  10. Fabre PH, Vilstrup JT, Raghavan M, Sarkissian CD, Willerslev E, Douzery EJ, Orlando L. Rodents of the Caribbean: origin and diversification of hutias unravelled by next-generation museomics. Biol Lett. 2014 Jul; 10(7). View in: PubMed

  11. Skoglund P, Malmström H, Omrak A, Raghavan M, Valdiosera C, Günther T, Hall P, Tambets K, Parik J, Sjögren KG, Apel J, Willerslev E, Storå J, Götherström A, Jakobsson M. Genomic diversity and admixture differs for Stone-Age Scandinavian foragers and farmers. Science. 2014 May 16; 344(6185):747-50. View in: PubMed

  12. Raghavan M, Skoglund P, Graf KE, Metspalu M, Albrechtsen A, Moltke I, Rasmussen S, Stafford TW, Orlando L, Metspalu E, Karmin M, Tambets K, Rootsi S, Mägi R, Campos PF, Balanovska E, Balanovsky O, Khusnutdinova E, Litvinov S, Osipova LP, Fedorova SA, Voevoda MI, DeGiorgio M, Sicheritz-Ponten T, Brunak S, Demeshchenko S, Kivisild T, Villems R, Nielsen R, Jakobsson M, Willerslev E. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature. 2014 Jan 02; 505(7481):87-91. View in: PubMed

  13. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson JF, Weinstock J, Gregersen K, Røed KH, Eisenmann V, Rubin CJ, Miller DC, Antczak DF, Bertelsen MF, Brunak S, Al-Rasheid KA, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert MT, Kjær K, Sicheritz-Ponten T, Jensen LJ, Olsen JV, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature. 2013 Jul 04; 499(7456):74-8. View in: PubMed

  14. Vilstrup JT, Seguin-Orlando A, Stiller M, Ginolhac A, Raghavan M, Nielsen SC, Weinstock J, Froese D, Vasiliev SK, Ovodov ND, Clary J, Helgen KM, Fleischer RC, Cooper A, Shapiro B, Orlando L. Mitochondrial phylogenomics of modern and ancient equids. PLoS One. 2013; 8(2):e55950. View in: PubMed

  15. Jenkins DL, Davis LG, Stafford TW, Campos PF, Hockett B, Jones GT, Cummings LS, Yost C, Connolly TJ, Yohe RM, Gibbons SC, Raghavan M, Rasmussen M, Paijmans JL, Hofreiter M, Kemp BM, Barta JL, Monroe C, Gilbert MT, Willerslev E. Clovis age Western Stemmed projectile points and human coprolites at the Paisley Caves. Science. 2012 Jul 13; 337(6091):223-8. View in: PubMed

  16. Skoglund P, Malmström H, Raghavan M, Storå J, Hall P, Willerslev E, Gilbert MT, Götherström A, Jakobsson M. Origins and genetic legacy of Neolithic farmers and hunter-gatherers in Europe. Science. 2012 Apr 27; 336(6080):466-9. View in: PubMed

  17. Orlando L, Ginolhac A, Raghavan M, Vilstrup J, Rasmussen M, Magnussen K, Steinmann KE, Kapranov P, Thompson JF, Zazula G, Froese D, Moltke I, Shapiro B, Hofreiter M, Al-Rasheid KA, Gilbert MT, Willerslev E. True single-molecule DNA sequencing of a pleistocene horse bone. Genome Res. 2011 Oct; 21(10):1705-19. View in: PubMed

  18. Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, Metspalu M, Metspalu E, Kivisild T, Gupta R, Bertalan M, Nielsen K, Gilbert MT, Wang Y, Raghavan M, Campos PF, Kamp HM, Wilson AS, Gledhill A, Tridico S, Bunce M, Lorenzen ED, Binladen J, Guo X, Zhao J, Zhang X, Zhang H, Li Z, Chen M, Orlando L, Kristiansen K, Bak M, Tommerup N, Bendixen C, Pierre TL, Grønnow B, Meldgaard M, Andreasen C, Fedorova SA, Osipova LP, Higham TF, Ramsey CB, Hansen TV, Nielsen FC, Crawford MH, Brunak S, Sicheritz-Pontén T, Villems R, Nielsen R, Krogh A, Wang J, Willerslev E. Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 2010 Feb 11; 463(7282):757-62. View in: PubMed

  19. Raghavan M, McCullagh JS, Lynnerup N, Hedges RE. Amino acid delta13C analysis of hair proteins and bone collagen using liquid chromatography/isotope ratio mass spectrometry: paleodietary implications from intra-individual comparisons. Rapid Commun Mass Spectrom. 2010 Mar 15; 24(5):541-8. View in: PubMed

  20. Papageorgopoulou C, Rentsch K, Raghavan M, Hofmann MI, Colacicco G, Gallien V, Bianucci R, Rühli F. Preservation of cell structures in a medieval infant brain: a paleohistological, paleogenetic, radiological and physico-chemical study. Neuroimage. 2010 Apr 15; 50(3):893-901. View in: PubMed

  21. Suter B, Fetchko MJ, Imhof R, Graham CI, Stoffel-Studer I, Zbinden C, Raghavan M, Lopez L, Beneti L, Hort J, Fillingham J, Greenblatt JF, Giaever G, Nislow C, Stagljar I. Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome Res. 2007 Dec; 17(12):1774-82. View in: PubMed