My group works in the areas of statistical genetics and mathematical statistics. Our investigations are motivated by applications to genetics and genomics studies on common/complex diseases, with a focus on asthma. Statistical genetics problems of interest include developing of statistical methodology for sequencing-based data, microbiome,large-scale data integration, networks and systems biology.
University of Chicago
PhD - Statistics
1999Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis. Allergy. 2023 10; 78(10):2698-2711.
PMID: 37571876Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings. PLoS Genet. 2023 01; 19(1):e1010594.
PMID: 36638096Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.
Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview. Curr Pediatr Rep. 2022; 10(3):57-92.
PMID: 36034212Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".
Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village". Curr Pediatr Rep. 2022; 10(3):125-154.
PMID: 35991908Building Programs to Eradicate Toxoplasmosis Part II: Education.
Building Programs to Eradicate Toxoplasmosis Part II: Education. Curr Pediatr Rep. 2022 Sep; 10(3):93-108.
PMID: 36969368Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55.
PMID: 35606880Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. Genome Med. 2021 10 10; 13(1):157.
PMID: 34629083Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 04 01; 203(7):864-870.
PMID: 33535024Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma.
Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma. Commun Biol. 2020 11 13; 3(1):678.
PMID: 33188283Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
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Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age. J Allergy Clin Immunol. 2020 12; 146(6):1358-1366.
PMID: 32693091