My research focus is on developing both new statistical methods and computational techniques to overcome the difficult problems in the analysis of genetic and genomic data. A primary interest is on developing models and approximations that are highly computationally efficient while leveraging as much of the information in the data as possible. As novel technologies are developed to collect ever larger and more specific genetic and genomic data, there arises a concurrent need for innovative methods to extract scientific insight from the data. My research focuses on developing such methods.
University of Chicago
Chicago
Ph.D. - Physics
1996
University of California San Diego
San Diego
B.S. - Physics
1989
Application of Equal Local Levels to Improve Q-Q Plot Testing Bands with R Package qqconf.
Application of Equal Local Levels to Improve Q-Q Plot Testing Bands with R Package qqconf. J Stat Softw. 2023; 106(10).
PMID: 37205880
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. Am J Hum Genet. 2020 Jan 02; 106(1):138.
PMID: 31901248
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. Am J Hum Genet. 2019 12 05; 105(6):1222-1236.
PMID: 31761296
Kinpute: using identity by descent to improve genotype imputation.
Kinpute: using identity by descent to improve genotype imputation. Bioinformatics. 2019 11 01; 35(21):4321-4326.
PMID: 30918937
Genome wide association analysis in a mouse advanced intercross line.
Genome wide association analysis in a mouse advanced intercross line. Nat Commun. 2018 12 04; 9(1):5162.
PMID: 30514929
Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci.
Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci. Mult Scler. 2018 12; 24(14):1815-1824.
PMID: 28933650
A LASSO penalized regression approach for genome-wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data.
A LASSO penalized regression approach for genome-wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data. BMC Proc. 2016; 10(Suppl 7):221-226.
PMID: 27980640
Directional dominance on stature and cognition in diverse human populations.
Directional dominance on stature and cognition in diverse human populations. Nature. 2015 Jul 23; 523(7561):459-462.
PMID: 26131930
Occurrence of Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) on Wild Hosts in Nonmanaged Woodlands and Soybean Fields in North Carolina and Virginia.
Occurrence of Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) on Wild Hosts in Nonmanaged Woodlands and Soybean Fields in North Carolina and Virginia. Environ Entomol. 2015 Aug; 44(4):1011-21.
PMID: 26314046
Permutation testing in the presence of polygenic variation.
Permutation testing in the presence of polygenic variation. Genet Epidemiol. 2015 May; 39(4):249-58.
PMID: 25758362