My research focus is on developing both new statistical methods and computational techniques to overcome the difficult problems in the analysis of genetic and genomic data. A primary interest is on developing models and approximations that are highly computationally efficient while leveraging as much of the information in the data as possible. As novel technologies are developed to collect ever larger and more specific genetic and genomic data, there arises a concurrent need for innovative methods to extract scientific insight from the data. My research focuses on developing such methods.
University of Chicago
Chicago
Ph.D. - Physics
1996
University of California San Diego
San Diego
B.S. - Physics
1989
Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons.
Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons. Cell Genom. 2024 Mar 13; 4(3):100509.
PMID: 38430910
ADELLE: A global testing method for Trans-eQTL mapping.
ADELLE: A global testing method for Trans-eQTL mapping. bioRxiv. 2024 Feb 26.
PMID: 38464248
Genetic regulatory effects in response to a high cholesterol, high fat diet in baboons.
Genetic regulatory effects in response to a high cholesterol, high fat diet in baboons. bioRxiv. 2023 Nov 20.
PMID: 37577666
BRASS: Permutation methods for binary traits in genetic association studies with structured samples.
BRASS: Permutation methods for binary traits in genetic association studies with structured samples. PLoS Genet. 2023 Nov; 19(11):e1011020.
PMID: 37934792
Application of Equal Local Levels to Improve Q-Q Plot Testing Bands with R Package qqconf.
Application of Equal Local Levels to Improve Q-Q Plot Testing Bands with R Package qqconf. J Stat Softw. 2023; 106(10).
PMID: 37205880
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. Am J Hum Genet. 2020 Jan 02; 106(1):138.
PMID: 31901248
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. Am J Hum Genet. 2019 12 05; 105(6):1222-1236.
PMID: 31761296
Kinpute: using identity by descent to improve genotype imputation.
Kinpute: using identity by descent to improve genotype imputation. Bioinformatics. 2019 11 01; 35(21):4321-4326.
PMID: 30918937
Genome wide association analysis in a mouse advanced intercross line.
Genome wide association analysis in a mouse advanced intercross line. Nat Commun. 2018 12 04; 9(1):5162.
PMID: 30514929
Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci.
Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci. Mult Scler. 2018 12; 24(14):1815-1824.
PMID: 28933650